Any product that is taken orally is broken down and absorbed through the intestinal tract. This transports the product into the liver where the majority of it is metabolised and excreted in the bile, which is known as "first pass loss". Because of this, the body captures and uses only about 10 to 15 percent of an oral dose..

Transdermal applications are those that are absorbed through the skin and into the layer of fat that is found beneath the skin's surface. Products that are applied transdermally have an immediate effect on the body. Oral doses must be far greater than transdermal doses in order to have an equivalent effect. Large oral doses result in a 1-2 hour peak followed by a quick decline and low levels for the rest of the day. These highs and lows are often confusing for the body, stifling its ability to response.

Transdermal application is the only method that matches the natural rate of release of hormones from the ovaries. Women who have used YouFemism often testify to the fast absorbency of the product and its ability to quickly relieve symptoms.